You can find data in Pfam in various ways. The purpose of this server is to make protein modelling accessible to all life. all UniProt and NCBI GI) or different levels of redundancy. SWISS-MODEL is a fully automated protein structure homology-modelling server. Pfam full alignments are available from searching a variety of databases, either to provide different accessions (e.g. The data presented for each entry is based on the UniProt Reference Proteomes but information on individual UniProtKB sequences can still be found by entering the protein accession. A clan is a collection of Pfam entries which are related by similarity of sequence, structure or profile-HMM. Pfam also generates higher-level groupings of related entries, known as clans. The identification of domains that occur within proteins can therefore provide insights into their function. Different combinations of domains give rise to the diverse range of proteins found in nature. Proteins are generally composed of one or more functional regions, commonly termed domains. The Pfam database is a large collection of protein families, each represented by multiple sequence alignments and hidden Markov models (HMMs).
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